Illness GBD, Harm I, Prevalence C. International, regional, and Nationwide incidence, prevalence, and years lived with incapacity for 328 ailments and accidents for 195 international locations, 1990–2016: a scientific evaluation for the worldwide burden of illness research 2016. Lancet (London England). 2017;390(10100):1211–59.
Penninx BWJH, Pine DS, Holmes EA, Reif A. Anxiousness issues. Lancet. 2021;397(10277):914–27.
Domschke Okay, Stevens S, Pfleiderer B, Gerlach AL. Interoceptive sensitivity in anxiousness and anxiousness issues: an summary and integration of Neurobiological findings. Clin Psychol Rev. 2010;30(1):1–11.
Paulus MP, Stein MB. Interoception in anxiousness and melancholy. Mind Struct Funct. 2010;214(5–6):451–63.
Bonaz B, Lane RD, Oshinsky ML, Kenny PJ, Sinha R, Mayer EA, et al. Illnesses, issues, and comorbidities of interoception. Traits Neurosci. 2021;44(1):39–51.
Bonaz B, Bazin T, Pellissier S. The vagus nerve on the interface of the microbiota-gut-brain axis. Entrance Neurosci. 2018;12:49.
Liu L, Zhu G. Intestine-Mind Axis and temper dysfunction. Entrance Psychiatry. 2018;9:223.
Aburto MR, Cryan JF. Gastrointestinal and mind limitations: unlocking gates of communication throughout the microbiota-gut-brain axis. Nat Rev Gastroenterol Hepatol. 2024;21(4):222–47.
Tysoe O. Mapping neuron capabilities within the gut-brain axis. Nat Rev Endocrinol. 2021;17(8):448.
Bai L, Mesgarzadeh S, Ramesh KS, Huey EL, Liu Y, Grey LA, et al. Genetic identification of vagal sensory neurons that management feeding. Cell. 2019;179(5):1129–e114323.
Schwartz GJ. The-pole of Gastrointestinal vagal afferents within the management of meals consumption: present prospects. Vitamin. 2000;16(10):866–73.
Han W, Tellez LA, Perkins MH, Perez IO, Qu T, Ferreira J, et al. A neural circuit for gut-induced reward. Cell. 2018;175(3):665–e67823.
Krieger JP, Asker M, van der Velden P, Boerchers S, Richard JE, Maric I, et al. Neural pathway for intestine emotions: vagal interoceptive suggestions from the Gastrointestinal tract is a essential modulator of anxiety-like habits. Biol Psychiatry. 2022;92(9):709–21.
Suarez AN, Hsu TM, Liu CM, Noble EE, Cortella AM, Nakamoto EM, et al. Intestine vagal sensory signaling regulates hippocampus perform by multi-order pathways. Nat Commun. 2018;9(1):2181.
Benarroch EE. The central autonomic community – functional-organization, dysfunction, and perspective. Mayo Clin Proc. 1993;68(10):988–1001.
Lyte M, Li W, Opitz N, Gaykema RPA, Goehler LE. Induction of anxiety-like habits in mice throughout the preliminary levels of an infection with the agent of murine colonic hyperplasia Citrobacter rodentium. Physiol Behav. 2006;89(3):350–7.
Goehler LE, Gaykema RPA, Opitz N, Reddaway R, Badr N, Lyte M. Activation in vagal afferents and central autonomic pathways: early responses to intestinal an infection with Campylobacter jejuni. Mind Behav Immun. 2005;19(4):334–44.
Hosoi T, Okuma Y, Nomura Y. Electrical stimulation of afferent vagus nerve induces IL-1beta expression within the mind and prompts HPA axis. Am J Physiol Regul Integr Comp Physiol. 2000;279(1):R141–7.
Klarer M, Arnold M, Guenther L, Winter C, Langhans W, Meyer U. Intestine vagal afferents differentially modulate innate anxiousness and discovered concern. J Neurosci. 2014;34(21):7067–76.
Egerod KL, Petersen N, Timshel PN, Rekling JC, Wang Y, Liu Q, et al. Profiling of G protein-coupled receptors in vagal afferents reveals novel gut-to-brain sensing mechanisms. Mol Metab. 2018;12:62–75.
Ho CL, Tan HQ, Chua KJ, Kang A, Lim KH, Ling KL, et al. Engineered commensal microbes for diet-mediated colorectal-cancer chemoprevention. Nat Biomed Eng. 2018;2(1):27–37.
Motta J-P, Bermudez-Humaran LG, Deraison C, Martin L, Rolland C, Rousset P et al. Meals-grade micro organism expressing Elafin defend towards irritation and restore colon homeostasis. Sci Transl Med. 2012;4(158).
Isabella VM, Ha BN, Castillo MJ, Lubkowicz DJ, Rowe SE, Millet YA, et al. Growth of an artificial dwell bacterial therapeutic for the human metabolic illness phenylketonuria. Nat Biotechnol. 2018;36(9):857–64.
Harimoto T, Hahn J, Chen YY, Im J, Zhang J, Hou N, et al. A programmable encapsulation system improves supply of therapeutic micro organism in mice. Nat Biotechnol. 2022;40(8):1259–69.
Guo P, Wang W, Xiang Q, Pan C, Qiu Y, Li T, et al. Engineered probiotic ameliorates ulcerative colitis by restoring intestine microbiota and redox homeostasis. Cell Host Microbe. 2024;32(9):1502–e15189.
Liu WZ, Zhang WH, Zheng ZH, Zou JX, Liu XX, Huang SH, et al. Identification of a prefrontal cortex-to-amygdala pathway for persistent stress-induced anxiousness. Nat Commun. 2020;11(1):2221.
Ducarmon QR, Zwittink RD, Hornung BVH, van Schaik W, Younger VB, Kuijper EJ. Intestine microbiota and colonization resistance towards bacterial enteric an infection. Microbiol Mol Biol Rev. 2019;83(3).
Centurion F, Basit AW, Liu J, Gaisford S, Rahim MA, Kalantar-Zadeh Okay. Nanoencapsulation for probiotic supply. ACS Nano. 2021;15(12):18653–60.
Hong S, Kim J, Na YS, Park J, Kim S, Singha Okay, et al. Poly(norepinephrine): ultrasmooth material-independent floor chemistry and nanodepot for nitric oxide. Angew Chem Int Ed Engl. 2013;52(35):9187–91.
Abdou AM, Higashiguchi S, Horie Okay, Kim M, Hatta H, Yokogoshi H. Leisure and immunity enhancement results of γ-Aminobutyric acid (GABA) administration in people. BioFactors. 2006;26(3):201–8.
Cryan JF, Dinan TG. Thoughts-altering microorganisms: the affect of the intestine microbiota on mind and behavior. Nat Rev Neurosci. 2012;13(10):701–12.
Landry BP, Tabor JJ. Engineering diagnostic and therapeutic intestine micro organism. Microbiol Spectr. 2017;5(5):10.
Riglar DT, Silver PA. Engineering micro organism for diagnostic and therapeutic functions. Nat Rev Microbiol. 2018;16(4):214–25.
Pan H, Solar T, Cui M, Ma N, Yang C, Liu J, et al. Mild-Delicate Lactococcus lactis for microbe-gut-brain axis regulating through upconversion optogenetic micro-nano system. ACS Nano. 2022;16(4):6049–63.
Riglar DT, Giessen TW, Baym M, Kerns SJ, Niederhuber MJ, Bronson RT, et al. Engineered micro organism can perform within the mammalian intestine long-term as dwell diagnostics of irritation. Nat Biotechnol. 2017;35(7):653–8.
Taketani M, Zhang J, Zhang S, Triassi AJ, Huang YJ, Griffith LG, et al. Genetic circuit design automation for the intestine resident species Bacteroides thetaiotaomicron. Nat Biotechnol. 2020;38(8):962–9.
Piraner DI, Abedi MH, Moser BA, Lee-Gosselin A, Shapiro MG. Tunable thermal bioswitches for in vivo management of microbial therapeutics. Nat Chem Biol. 2017;13(1):75–80.
Moros M, Idiago-López J, Asín L, Moreno-Antolín E, Beola L, Grazú V, et al. Triggering antitumoural drug launch and gene expression by magnetic hyperthermia. Adv Drug Deliv Rev. 2019;138:326–43.
Wu F, Liu J. Embellished micro organism and the appliance in drug supply. Adv Drug Deliv Rev. 2022;188:114443.
Cao Z, Wang X, Pang Y, Cheng S, Liu J. Biointerfacial self-assembly generates lipid membrane coated micro organism for enhanced oral supply and therapy. Nat Commun. 2019;10(1):5783.
Anselmo AC, McHugh KJ, Webster J, Langer R, Jaklenec A. Layer-by-layer encapsulation of probiotics for supply to the Microbiome. Adv Mater. 2016;28(43):9486–90.
Goehler LE, Gaykema RP, Opitz N, Reddaway R, Badr N, Lyte M. Activation in vagal afferents and central autonomic pathways: early responses to intestinal an infection with Campylobacter jejuni. Mind Behav Immun. 2005;19(4):334–44.
Krieger JP, Asker M, van der Velden P, Börchers S, Richard JE, Maric I, et al. Neural pathway for intestine emotions: vagal interoceptive suggestions from the Gastrointestinal tract is a essential modulator of anxiety-like habits. Biol Psychiatry. 2022;92(9):709–21.
Herman JP, Figueiredo H, Mueller NK, Ulrich-Lai Y, Ostrander MM, Choi DC, et al. Central mechanisms of stress integration: hierarchical circuitry controlling hypothalamo-pituitary-adrenocortical responsiveness. Entrance Neuroendocrinol. 2003;24(3):151–80.
Bains JS, Wamsteeker Cusulin JI, Inoue W. Stress-related synaptic plasticity within the hypothalamus. Nat Rev Neurosci. 2015;16(7):377–88.
Holt MK. The Ins and outs of the caudal nucleus of the solitary tract: an summary of mobile populations and anatomical connections. J Neuroendocrinol. 2022;34(6):e13132.
McCall JG, Al-Hasani R, Siuda ER, Hong DY, Norris AJ, Ford CP, Bruchas MR. CRH engagement of the locus coeruleus noradrenergic system mediates Stress-Induced anxiousness. Neuron. 2015;87(3):605–20.
McCall JG, Siuda ER, Bhatti DL, Lawson LA, McElligott ZA, Stuber GD, et al. Locus coeruleus to basolateral amygdala noradrenergic projections promote anxiety-like habits. Elife. 2017;6:e18247.
Zerbi V, Floriou-Servou A, Markicevic M, Vermeiren Y, Sturman O, Privitera M, et al. Speedy reconfiguration of the practical connectome after chemogenetic locus coeruleus activation. Neuron. 2019;103(4):702–e185.
Sciolino NR, Plummer NW, Chen YW, Alexander GM, Robertson SD, Dudek SM, et al. Recombinase-dependent mouse strains for chemogenetic activation of genetically outlined cell sorts. Cell Rep. 2016;15(11):2563–73.
McCall JG, Al-Hasani R, Siuda ER, Hong DY, Norris AJ, Ford CP, et al. CRH engagement of the locus coeruleus noradrenergic system mediates stress-induced anxiousness. Neuron. 2015;87(3):605–20.
Lee B, Shim I, Lee H, Hahm DH. Impact of ginsenoside re on depression- and anxiety-like behaviors and cognition reminiscence deficit induced by repeated immobilization in rats. J Microbiol Biotechnol. 2012;22(5):708–20.
Lee B, Yun HY, Shim I, Lee H, Hahm DH. Bupleurum falcatum prevents melancholy and anxiety-like behaviors in rats uncovered to repeated restraint stress. J Microbiol Biotechnol. 2012;22(3):422–30.
Navarro-Tapia E, Almeida-Toledano L, Sebastiani G, Serra-Delgado M, Garcia-Algar O, Andreu-Fernandez V. Results of microbiota imbalance in anxiousness and consuming issues: probiotics as novel therapeutic approaches. Int J Mol Sci. 2021;22(5):2351.
Kozin SV, Kravtsov AA, Kravchenko SV, Ivashchenko LI. Antioxidant and anxiolytic impact of Bifidobacterium adolescentis and Lactobacillus acidophilus underneath situations of Normobaric hypoxia with hypercapnia. Vopr Pitan. 2021;90(2):63–72.
Niu Y, Liang S, Wang T, Hu X, Li W, Wu X, Jin F. Pre-Gestational consumption of Lactobacillus helveticus NS8 has anxiolytic results in adolescent Sprague Dawley offspring. Mind Behav. 2020;10(9):e01714.
Olorocisimo JP, Diaz LA, Co DE, Carag HM, Ibana JA, Velarde MC. Lactobacillus delbrueckii reduces anxiety-like habits in zebrafish by a intestine microbiome-brain crosstalk. Neuropharmacology. 2023;225:109401.
Zheng KY, Gao B, Wang HJ, He JG, Chen HS, Hu ZL, et al. Melatonin ameliorates depressive-like behaviors in ovariectomized mice by bettering Tryptophan metabolism through Inhibition of intestine microbe Alistipes Inops. Adv Sci (Weinh). 2024;11(34):e2309473.
Music X, Wang W, Ding S, Liu X, Wang Y, Ma H. Puerarin ameliorates depression-like behaviors of with persistent unpredictable gentle stress mice by transforming their intestine microbiota. J Have an effect on Disord. 2021;290:353–63.
Simpson CA, Diaz-Arteche C, Eliby D, Schwartz OS, Simmons JG, Cowan CSM. The intestine microbiota in anxiousness and melancholy – A scientific evaluation. Clin Psychol Rev. 2021;83:101943.
van de Wouw M, Boehme M, Lyte JM, Wiley N, Pressure C, O’Sullivan O, Clarke G, Stanton C, Dinan TG, Cryan JF. Quick-chain fatty acids: microbial metabolites that alleviate stress-induced brain-gut axis alterations. J Physiol. 2018;596(20):4923–44.
Chen H, Zhang L, Li Y, Meng X, Chi Y, Liu M. Intestine microbiota and its metabolites: the rising Bridge between coronary artery illness and anxiousness and melancholy? Ageing Dis. 2024;16(3):1265–84.
Jiang H, Ling Z, Zhang Y, Mao H, Ma Z, Yin Y, et al. Altered fecal microbiota composition in sufferers with main depressive dysfunction. Mind Behav Immun. 2015;48:186–94.
Navarro-Tapia E, Almeida-Toledano L, Sebastiani G, Serra-Delgado M, García-Algar Ó, Andreu-Fernández V. Results of microbiota imbalance in anxiousness and consuming issues: probiotics as novel therapeutic approaches. Int J Mol Sci. 2021;22(5):2351.