Nanoplastics (NPs) are widespread in ecosystems and their biohazards are of accelerating concern. The hazards of NPs to aquatic and terrestrial vegetation and aquatic animals have been extensively studied, whereas the hazards to mammals are nonetheless being explored. Right here, we carried out a meta-analysis to quantify the final depth of NPs results on mice and developed two machine studying strategies to foretell the correlates of the detrimental results of NPs. We discovered that NPs have a variety of poisonous results on numerous programs, and their hostile results have been primarily associated to toxicity metrics, adopted by the scale, sort, and mass focus of NPs, in addition to publicity routes, publicity time, and mouse gender. These outcomes counsel that the toxicity of NPs to mammals depends upon numerous responses starting from the molecular to the bioindividual scale, that are influenced by the properties of the NPs themselves and by environmental circumstances that complicate their toxicity and have a variety of results.