Pavlova, N. N. & Thompson, C. B. The rising hallmarks of most cancers metabolism. Cell Metab. 23, 27–47 (2016).
Altea-Manzano, P., Decker-Farrell, A., Janowitz, T. & Erez, A. Metabolic interplays between the tumour and the host form the tumour macroenvironment. Nat. Rev. Most cancers 25, 274–292 (2025).
Vander Heiden, M. G., Cantley, L. C. & Thompson, C. B. Understanding the Warburg impact: the metabolic necessities of cell proliferation. Science 324, 1029–1033 (2009).
Kitazawa, M. et al. Promotion of the Warburg impact is related to poor profit from adjuvant chemotherapy in colorectal most cancers. Most cancers Sci. 111, 658–666 (2020).
Stine, Z. E., Schug, Z. T., Salvino, J. M. & Dang, C. V. Focusing on most cancers metabolism within the period of precision oncology. Nat. Rev. Drug Discov. 21, 141–162 (2022).
DeBerardinis, R. J. & Keshari, Okay. R. Metabolic evaluation as a driver for discovery, prognosis, and remedy. Cell 185, 2678–2689 (2022).
Shao, H. et al. New applied sciences for evaluation of extracellular vesicles. Chem. Rev. 118, 1917–1950 (2018).
O’Brien, Okay., Breyne, Okay., Ughetto, S., Laurent, L. C. & Breakefield, X. O. RNA supply by extracellular vesicles in mammalian cells and its functions. Nat. Rev. Mol. Cell Biol. 21, 585–606 (2020).
Dixson, A. C., Dawson, T. R., Di Vizio, D. & Weaver, A. M. Context-specific regulation of extracellular vesicle biogenesis and cargo choice. Nat. Rev. Mol. Cell Biol. 24, 454–476 (2023).
Thomas, S. N., French, D., Jannetto, P. J., Rappold, B. A. & Clarke, W. A. Liquid chromatography–tandem mass spectrometry for scientific diagnostics. Nat. Rev. Strategies Primers 2, 96 (2022).
Fochtman, D., Marczak, L., Pietrowska, M. & Wojakowska, A. Challenges of MS-based small extracellular vesicles proteomics. J. Extracell. Vesicles 13, e70020 (2024).
Xiao, L. et al. Untargeted tumor metabolomics with liquid chromatography–surface-enhanced Raman spectroscopy. Angew. Chem. Int. Ed. 59, 3439–3443 (2020).
Lysak, D. H., Downey, Okay., Cahill, L. S., Bermel, W. & Simpson, A. J. In vivo NMR spectroscopy. Nat. Rev. Strategies Primers 3, 91 (2023).
Liu, H. et al. Vitality metabolism in well being and illnesses. Sign Transduct. Goal. Ther. 10, 69 (2025).
Shamsabadi, A., Haghighi, T., Carvalho, S., Frenette, L. C. & Stevens, M. M. The nanozyme revolution: enhancing the efficiency of medical biosensing platforms. Adv Mater 36, e2300184 (2024).
Breger, J. C. et al. Self assembling nanoparticle enzyme clusters present entry to substrate channeling in multienzymatic cascades. Nat. Commun. 14, 1757 (2023).
Ju, Y. et al. Floor enzyme-polymerization endows Janus hydrogel robust adhesion and regenerative restore in penetrating orocutaneous fistulas. Nat. Commun. 15, 10903 (2024).
Li, X. et al. Extremely lively enzyme–steel nanohybrids synthesized in protein–polymer conjugates. Nat. Catal. 2, 718–725 (2019).
Zheng, D. et al. Co-immobilization of entire cells and enzymes by covalent natural framework for biocatalysis course of intensification. Nat. Commun. 15, 5510 (2024).
Chen, W. H., Vázquez-González, M., Zoabi, A., Abu-Reziq, R. & Willner, I. Biocatalytic cascades pushed by enzymes encapsulated in steel–natural framework nanoparticles. Nat. Catal. 1, 689–695 (2018).
Chen, G., Huang, S., Ma, X., He, R. & Ouyang, G. Encapsulating and stabilizing enzymes utilizing hydrogen-bonded natural frameworks. Nat. Protoc. 18, 2032–2050 (2023).
Hao, X. et al. Engineering enzyme conformation inside liquid–stable hybrid microreactors for enhanced continuous-flow biocatalysis. Nat. Commun. 15, 10440 (2024).
Liu, Q. et al. Cofactor-free oxidase-mimetic nanomaterials from self-assembled histidine-rich peptides. Nat. Mater. 20, 395–402 (2021).
Broto, M. et al. Nanozyme-catalysed CRISPR assay for preamplification-free detection of non-coding RNAs. Nat. Nanotechnol. 17, 1120–1126 (2022).
Su, J. et al. Single-site iron-anchored amyloid hydrogels as catalytic platforms for alcohol cleansing. Nat. Nanotechnol. 19, 1168–1177 (2024).
Grey, H. B. & Winkler, J. R. Lengthy-range electron switch. Proc. Natl Acad. Sci. USA 102, 3534–3539 (2005).
Lagunas, A. et al. Lengthy distance electron switch by the aqueous answer between redox accomplice proteins. Nat. Commun. 9, 5157 (2018).
Holland, J. T., Lau, C., Brozik, S., Atanassov, P. & Banta, S. Engineering of glucose oxidase for direct electron switch by way of site-specific gold nanoparticle conjugation. J. Am. Chem. Soc. 133, 19262–19265 (2011).
Zaffaroni, R., Bobylev, E. O., Plessius, R., van der Vlugt, J. I. & Reek, J. N. H. How one can management the speed of heterogeneous electron switch throughout the rim of M6L12 and M12L24 nanospheres. J. Am. Chem. Soc. 142, 8837–8847 (2020).
Yang, Y. et al. Twin H2O2 manufacturing paths over chemically etched MoS2/FeS2 heterojunction: maximizing self-sufficient heterogeneous Fenton response fee beneath the impartial situation. Appl. Catal. B 325, 122307 (2023).
Welsh, J. A. et al. Minimal data for research of extracellular vesicles (MISEV2023): from fundamental to superior approaches. J. Extracell. Vesicles 13, e12404 (2024).
Li, X. et al. Lactate metabolism in human well being and illness. Sign Transduct. Goal. Ther. 7, 305 (2022).
Yoshioka, Y. et al. Comparative marker evaluation of extracellular vesicles in numerous human most cancers varieties. J. Extracell. Vesicles 2, 20424 (2013).
Denko, N. C. Hypoxia, HIF1 and glucose metabolism within the stable tumour. Nat. Rev. Most cancers 8, 705–713 (2008).
Im, H. et al. Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor. Nat. Biotechnol. 32, 490–495 (2014).
Galluzzi, L., Smith, Okay. N., Liston, A. & Garg, A. D. The variety of CD8+ T cell dysfunction in most cancers and viral an infection. Nat. Rev. Immunol. 25, 662–679 (2025).
Huang, H. et al. Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce growth of regulatory T cells in pancreatic most cancers. Most cancers Cell 40, 656–673.e7 (2022).
Liu, S., Liao, S., Liang, L., Deng, J. & Zhou, Y. The connection between CD4+ T cell glycolysis and their features. Tendencies Endocrinol. Metab. 34, 345–360 (2023).
Tang, X. et al. Glycolysis inhibition induces anti-tumor central reminiscence CD8+ T cell differentiation upon mixture with microwave ablation remedy. Nat. Commun. 15, 4665 (2024).
Hanahan, D. & Weinberg, R. A. Hallmarks of most cancers: the following era. Cell 144, 646–674 (2011).
Xia, L. et al. The most cancers metabolic reprogramming and immune response. Mol. Most cancers 20, 28 (2021).
Fu, W. et al. Enzyme-controlled stereoselective radical cyclization to arenes enabled by metalloredox biocatalysis. Nat. Catal. 6, 628–636 (2023).
Lister, T. M. et al. Engineered enzymes for enantioselective nucleophilic fragrant substitutions. Nature 639, 375–381 (2025).
Kernohan, Okay. D. & Boycott, Okay. M. The increasing diagnostic toolbox for uncommon genetic illnesses. Nat. Rev. Genet. 25, 401–415 (2024).
Carrasco-Zanini, J. et al. Proteomic signatures enhance threat prediction for widespread and uncommon illnesses. Nat. Med. 30, 2489–2498 (2024).
Tavallaie, R. et al. Nucleic acid hybridization on an electrically reconfigurable community of gold-coated magnetic nanoparticles permits microRNA detection in blood. Nat. Nanotechnol. 13, 1066–1071 (2018).
Hao, L. et al. CRISPR-Cas-amplified urinary biomarkers for multiplexed and moveable most cancers diagnostics. Nat. Nanotechnol. 18, 798–807 (2023).
Zhong, Z. et al. Sequence-specific nanoparticle barcode technique for multiplex human enterovirus typing. Nat. Commun. 15, 6478 (2024).
Pan, S. et al. Extracellular vesicle drug occupancy permits real-time monitoring of focused most cancers remedy. Nat. Nanotechnol. 16, 734–742 (2021).
Cheng, P. et al. Urinary bioorthogonal reporters for the monitoring of the efficacy of chemotherapy for lung most cancers and of related kidney harm. Nat. Biomed. Eng. 9, 686–699 (2025).
Wang, Y. et al. Engineering nanozyme immunomodulator with magnetic focusing on impact for cascade-enzyodynamic and ultrasound-reinforced metallo-immunotherapy in prostate carcinoma. Nat. Commun. 16, 1876 (2025).
Zhang, Y., Wang, C. & Shao, H. Nanoplasmonic sensing of heterogeneous extracellular vesicles: from bulk to single vesicles. Small Strategies 9, e2500097 (2025).
Natalia, A., Zhang, L., Sundah, N. R., Zhang, Y. & Shao, H. Analytical machine miniaturization for the detection of circulating biomarkers. Nat. Rev. Bioeng. 1, 481–498 (2023).
Abraham, M. J. et al. GROMACS: excessive efficiency molecular simulations by multi-level parallelism from laptops to supercomputers. SoftwareX 1, 19–25 (2015).
VMD (College of Illinois at Urbana-Champaign); https://www.ks.uiuc.edu/Analysis/vmd/. (accessed 7 Feb 2025)
Kim, Y. et al. Pure cubic-phase hybrid iodobismuthates AgBi2I7 for thin-film photovoltaics. Angew. Chem. Int. Ed. 55, 9586–9590 (2016).
Wang, H. et al. Redox move batteries: easy methods to decide electrochemical kinetic parameters. ACS Nano 14, 2575–2584 (2020).
Kresse, G. & Furthmüller, J. Environment friendly iterative schemes for ab initio total-energy calculations utilizing a plane-wave foundation set. Phys. Rev. B 54, 11169–11186 (1996).
Jiang, B. et al. Standardized assays for figuring out the catalytic exercise and kinetics of peroxidase-like nanozymes. Nat. Protoc. 13, 1506–1520 (2018).
Zhuo, Y. et al. Direct cytosolic supply of siRNA by way of cell membrane fusion utilizing cholesterol-enriched exosomes. Nat. Nanotechnol. 19, 1858–1868 (2024).
Wiemann, J., Nguyen, D., Li, Y. & Yu, Y. Area-selective disruption and compression of phase-separated lipid vesicles by amphiphilic Janus nanoparticles. iScience 25, 105525 (2022).
Sangisetty, S. L. & Miner, T. J. Malignant ascites: a evaluation of prognostic elements, pathophysiology and therapeutic measures. World J. Gastrointest. Surg. 4, 87–95 (2012).
Valletti, M. et al. Gastric most cancers with constructive peritoneal cytology: survival profit after induction chemotherapy and conversion to damaging peritoneal cytology. World J. Surg. Oncol. 19, 245 (2021).
Vallejo, J. S. A. et al. Assessing morbidity, mortality, and survival in sufferers with peritoneal carcinomatosis present process cytoreductive surgical procedure and hyperthermic intraperitoneal chemotherapy. Rev. Col. Bras. Cir. 50, e20233421 (2023).
Khoo, B. L. Early detection of metastasis in ascites and peritoneal lavage—new views utilizing label-free microfluidic approaches. eBioMedicine 91, 104554 (2023).
Kim, D.-W. Intraoperative peritoneal lavage: limitations of present proof for scientific implementation. Ann. Coloproctol. 30, 248–249 (2014).