Suboptimal reactive oxygen species (ROS) manufacturing in photodynamic remedy (PDT) and chemodynamic remedy (CDT) as a result of tumor antioxidants and H2O2 constraints poses a problem to their therapeutic efficacy. To deal with this, our examine introduces GOx@MPN@Gel, a novel PDT/CDT platform that integrates glucose oxidase (GOx), luteolin, iron ions, a conventional Chinese language medicine-inspired metal-phenolic community (MPN), and hydrogel (Gel) carriers to reinforce ROS era. Experimental outcomes display GOx@MPN@Gel heightened acid sensitivity, strong GOx exercise, and vital ROS manufacturing. Each in vitro and in vivo checks validate its therapeutic potential. Throughout the tumor microenvironment, GOx@MPN@Gel successfully elevates H2O2 ranges for CDT, producing cytotoxic hydroxyl radicals (·OH), and upon close to infrared (NIR) gentle publicity, its porphyrin element triggers potent PDT results, producing further ROS. This synergistic strategy considerably enhances antitumor efficacy. The platform’s distinctive design, combining acid-responsive degradation and PDT/CDT synergy, affords a promising personalised therapy technique for breast most cancers.
