Electrophysiological indicators, generated from the directional transport of ions throughout mobile membranes, encode very important physiological data related to human well being standing. Electrophysiological sign monitoring serves as a crucial strategy for deciphering basic physiological processes and enabling exact illness diagnostics. Bioelectrodes are indispensable parts for the acquisition of high-fidelity electrophysiological indicators. Nonetheless, sweat inevitably accumulates on the pores and skin–electrode interface throughout steady monitoring, which can irritate the pores and skin or trigger the electrodes to detach from the pores and skin, affecting the acquisition of high-quality electrophysiological indicators. A key problem in making certain the long-term utility of bioelectrodes lies in enhancing their breathability with out impeding electrophysiological sign transmission. Subsequently, we realized Ti3C2Tx edge passivation by NaAsc and the preservation time at room temperature was elevated to 30 days. On this foundation, an antioxidant Ti3C2Tx bioelectrode with excessive air permeability and biocompatibility was proposed. The bioelectrode has a wonderful fuel permeability of 1408.89 g m−2 d−1 and a low pores and skin–electrode interface impedance of 1.83 × 105 Ω at 10 Hz. Furthermore, the signal-to-noise ratio of the electromyography sign is nineteen.4 dB and the T/R wave depth ratio of the electrocardiography sign is 0.4079, which is superior to that of the Ag/AgCl gel electrode. The bioelectrode with these optimized attributes allows steady, long-term monitoring of a number of electrophysiological modalities and glorious pores and skin biocompatibility, offering a brand new strategy for setting up a well being monitoring and good medical system.